IMAGIC-5
Advanced Scientific Image Processing
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Description
Relevant Pointers
Typical results, references
Manuals
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IMAGIC-5 formats
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IMAGIC-5: Description
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IMAGIC-5 is a high end environment for the analysis of images,
spectra and other multi-dimensional data-sets.
IMAGIC-5's software package is aimed at processing (huge) data
sets from (cryo-) electron microscopy, especially in the field
of single particle analyses in Structural Biology.
IMAGIC-5 can also be used in light and raster-tunnelling microscopes,
computer tomographs, FT-IR spectrometers and other signal
collecting devices. Even protein sequences from full data banks
have been processed.
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Multi-dimensional mixed-radix Fourier transforms (limited by disk
space only),
correlation analysis,
alignments,
three-dimensional reconstruction from projections
and
morphometry,
are all standard procedures in this floating
point oriented data processing system.
The multivariate statistical pattern recognition procedures
(MSA)
of IMAGIC-5 are geared at extracting the essential information
from large and complex data-sets in various disciplines like
biology, medicine and environmental sciences. These MSA procedures
render huge, noisy data sets manageable and understandable. A
friendly and transparent user-interface with local interactive
help at all levels completes the application-oriented user
extendible IMAGIC-5.
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The three-dimensional data processing and angular reconstitution
modules
allow the three-dimensional reconstruction
of biological macromolecules with arbitrary
point-group symmetry from their two-dimensional electron
microscopical projections. By exploiting the different orientations
of the molecules in the embedding medium, one may extract 3D
information from the data without ever collecting tilt series in
the microscope. The simplicity of this approach allows fast and
unproblematic 3D analysis of biological macromolecules with high
resolution.
IMAGIC-5 is running on various Linux / UNIX computers as well as
under MS Windows and Intel based OSX Mac computers.
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